Hepcidin – publications
Gutschow P. Researcher's Guide to Hepcidin Testing
Evaluation of Hepcidin Level in COVID-19 Patients Admitted to the Intensive Care Unit
Pediatr Nephrol.
Diagnostics (Basel) 2022 Nov 2;12(11):2665. doi: 10.3390/diagnostics12112665 https://pubmed.ncbi.nlm.nih.gov/36359509/
Associations among erythropoietic, iron-related, and FGF23 parameters in pediatric kidney transplant recipients
Blair Limm-Chan, Katherine Wesseling-Perry, Meghan H. Pearl, Grace Jung, Eileen Tsai-Chambers, Patricia L. Weng, Mark R. Hanudel. Pediatr Nephrol. 2021 October ; 36(10): 3241–3249. https://pubmed.ncbi.nlm.nih.gov/33903951/
Increased serum catalytic iron may mediate tissue injury and death in patients with COVID‑19
Vipul Chakurkar, Mohan Rajapurkar, Suhas Lele, Banibrata Mukhopadhyay, Valentine Lobo, Ramakrishna Injarapu, Muddassir Sheikh. Scientific Reports | (2021) 11:19618. https://pubmed.ncbi.nlm.nih.gov/20444958/
Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation
. The American Journal of Clinical Nutrition, Volume 92, Issue 1, July 2010, Pages 93–100. https://pubmed.ncbi.nlm.nih.gov/20444958/
Mechanisms responsible for reduced erythropoiesis during androgen deprivation therapy in men with prostate cancer
. Am J Physiol Endocrinol Metab 315: E1185–E1193, 2018. https://pubmed.ncbi.nlm.nih.gov/30325657/
Hepcidin and arterial stiffness in children with systemic lupus erythematosus and lupus nephritis: A cross-sectional study
, 2019 Mar 29;14(3):e0214248. doi: 10.1371/journal.pone.0214248. eCollection 2019. https://pubmed.ncbi.nlm.nih.gov/30925172/
Hepcidin levels predict Covid- 19 severity and mortality in a cohort of hospitalized Italian patients
Antonella Nai, Nicola Ivan Lorè, Alessia Pagani, Rebecca De Lorenzo, Simona Di Modica, Fabio Saliu, DOI: 10.1002/ajh.26027 15 October 2020. https://pubmed.ncbi.nlm.nih.gov/33075189/
Predictive Value of Plasma NGAL:Hepcidin-25 for Major Adverse Kidney Events After Cardiac Surgery with Cardiopulmonary Bypass: A Pilot Study
Christian Albert, Michael Haase, Annemarie Albert, Martin Ernst, Siegfried Kropf, Rinaldo Bellomo, Sabine Westphal. Ann Lab Med 2021;41:357-365. https://pubmed.ncbi.nlm.nih.gov/33536353/
Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors.
Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. J Appl Lab Med. 2020 5(5):943-953. https://pubmed.ncbi.nlm.nih.gov/32674118/
Hepcidin Status at 2 Months in Infants Fed Breast Milk Compared with Formula.
Verhaeghe R, George K, Westerman M, Olbina G, McCann D, Parrow N, Pincus E, Havranek T, Fleming RE. Neonatology. 2020 20:1-6. https://pubmed.ncbi.nlm.nih.gov/32818935/
Urinary Biomarkers may Complement the Cleveland Score for Prediction of Adverse Kidney Events After Cardiac Surgery: A Pilot Study.
Albert C, Haase M, Albert A, Kropf S, Bellomo R, Westphal S, Westerman M, Braun-Dullaeus RC, Haase-Fielitz A. Ann Lab Med. 2020 40(2):131-141. https://pubmed.ncbi.nlm.nih.gov/31650729/
Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material.
Diepeveen LE, Laarakkers CMM, Martos G, Pawlak ME, Uğuz FF, Verberne KESA, van Swelm RPL, Klaver S, de Haan AFJ, Pitts KR, Bansal SS, Abbas IM, Fillet M, Lefebvre T, Geurts-Moespot AJ, Girelli D, Castagna A, Herkert M, Itkonen O, Olbina G, Tomosugi N, Westerman ME, Delatour V, Weykamp CW, Swinkels DW. Clin Chem Lab Med. 2019 57(6):864-872. https://pubmed.ncbi.nlm.nih.gov/30485171/
Effect of calcitriol on serum hepcidin in individuals with chronic kidney disease: a randomized controlled trial.
Panwar B, McCann D, Olbina G, Westerman M, Gutiérrez OM. BMC Nephrol. 2018 19(1):35. https://pubmed.ncbi.nlm.nih.gov/29426300/
Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency.
Heeney MM, Guo D, De Falco L, Campagna DR, Olbina G, Kao PP, Schmitz-Abe K, Rahimov F, Gutschow P, Westerman K, Ostland V, Jackson T, Klaassen RJ, Markianos K, Finberg KE, Iolascon A, Westerman M, London WB, Fleming MD. Blood. 2018 132(4):448-452. https://pubmed.ncbi.nlm.nih.gov/29895660/
Iron-related markers are associated with infection after liver transplantation.
Chow JKL, Ganz T, Ruthazer R, Simpson MA, Pomfret EA, Gordon FD, Westerman ME, Snydman DR. Liver Transpl. 2017 23(12):1541-1552. https://pubmed.ncbi.nlm.nih.gov/28703464/
Prepregnancy Body Mass Index and Gestational Weight Gain Have No Negative Impact on Maternal or Neonatal Iron Status.
Cao C, Pressman EK, Cooper EM, Guillet R, Westerman M, O’Brien KO. Reprod Sci. 2016 23(5):613-22. https://pubmed.ncbi.nlm.nih.gov/26423600/
A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial.
Brigandi RA, Johnson B, Oei C, Westerman M, Olbina G, de Zoysa J, Roger SD, Sahay M, Cross N, McMahon L, Guptha V, Smolyarchuk EA, Singh N, Russ SF, Kumar S; PHI112844 Investigators. Am J Kidney Dis. 2016 67(6):861-71. https://pubmed.ncbi.nlm.nih.gov/26827289/
Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation.
Chen H, Choesang T, Li H, Sun S, Pham P, Bao W, Feola M, Westerman M, Li G, Follenzi A, Blanc L, Rivella S, Fleming RE, Ginzburg YZ. Haematologica. 2016 101(3):297-308. https://pubmed.ncbi.nlm.nih.gov/26635037/
Evidence of relative iron deficiency in platelet- and plasma-pheresis donors correlates with donation frequency.
Li H, Condon F, Kessler D, Nandi V, Rebosa M, Westerman M, Shaz BH, Ginzburg Y. J Clin Apher. 2016 31(6):551-558. https://pubmed.ncbi.nlm.nih.gov/26915437/
Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material.
van der Vorm LN, Hendriks JC, Laarakkers CM, Klaver S, Armitage AE, Bamberg A, Geurts-Moespot AJ, Girelli D, Herkert M, Itkonen O, Konrad RJ, Tomosugi N, Westerman M, Bansal SS, Campostrini N, Drakesmith H, Fillet M, Olbina G, Pasricha SR, Pitts KR, Sloan JH, Tagliaro F, Weykamp CW, Swinkels DW. Clin Chem. 2016 62(7):993-1001. https://pubmed.ncbi.nlm.nih.gov/27173010/
Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents.
Lee S, Guillet R, Cooper EM, Westerman M, Orlando M, Kent T, Pressman E, O'Brien KO. Pediatr Res. 2016 79(1-1):42-8. https://pubmed.ncbi.nlm.nih.gov/26383884/
Short-Term Effects of Blood Transfusions on Hepcidin in Preterm Infants.
Lorenz L, Müller KF, Poets CF, Peter A, Olbina G, Westerman M, Franz AR. Neonatology. 2015 108(3):205-10. https://pubmed.ncbi.nlm.nih.gov/26304233/
A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis.
Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. Haematologica. 2015 100(2):167-77. https://pubmed.ncbi.nlm.nih.gov/25425686/
Urinary neutrophil gelatinase-associated lipocalin to hepcidin ratio as a biomarker of acute kidney injury in intensive care unit patients.
Mårtensson J, Glassford NJ, Jones S, Eastwood GM, Young H, Peck L, Ostland V, Westerman M, Venge P, Bellomo R. Minerva Anestesiol. 2015 81(11):1192-200. https://pubmed.ncbi.nlm.nih.gov/25479470/
Altered erythropoiesis and iron metabolism in carriers of thalassemia.
Guimarães JS, Cominal JG, Silva-Pinto AC, Olbina G, Ginzburg YZ, Nandi V, Westerman M, Rivella S, de Souza AM. Eur J Haematol. 2015 94(6):511-8. https://pubmed.ncbi.nlm.nih.gov/25307880/
Combination of biomarkers for diagnosis of acute kidney injury after cardiopulmonary bypass.
Prowle JR, Calzavacca P, Licari E, Ligabo EV, Echeverri JE, Bagshaw SM, Haase-Fielitz A, Haase M, Ostland V, Noiri E, Westerman M, Devarajan P, Bellomo R. Ren Fail. 2015 Apr;37(3):408-16. https://pubmed.ncbi.nlm.nih.gov/25585949/
Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.
Schmidt PJ, Racie T, Westerman M, Fitzgerald K, Butler JS, Fleming MD. Am J Hematol. 2015 90(4):310-3. https://pubmed.ncbi.nlm.nih.gov/25557851/
Erythropoiesis-driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15.
Fertrin KY, Lanaro C, Franco-Penteado CF, de Albuquerque DM, de Mello MR, Pallis FR, Bezerra MA, Hatzlhofer BL, Olbina G, Saad ST, da Silva Araújo A, Westerman M, Costa FF. Am J Hematol. 2014 89(4):385-90. https://pubmed.ncbi.nlm.nih.gov/24860871/
Suppression of iron-regulatory hepcidin by vitamin D.
Bacchetta J, Zaritsky JJ, Sea JL, Chun RF, Lisse TS, Zavala K, Nayak A, Wesseling-Perry K, Westerman M, Hollis BW, Salusky IB, Hewison M. J Am Soc Nephrol. 2014 25(3):564-72. https://pubmed.ncbi.nlm.nih.gov/24204002/
Gestational age-specific reference ranges of hepcidin in cord blood.
Lorenz L, Herbst J, Engel C, Peter A, Abele H, Poets CF, Westerman M, Franz AR. Neonatology. 2014 106(2):133-9. https://pubmed.ncbi.nlm.nih.gov/24993575/
Maternal inflammation at delivery affects assessment of maternal iron status.
Lee S, Guillet R, Cooper EM, Westerman M, Orlando M, Pressman E, O'Brien KO. J Nutr. 2014 144(10):1524-32. https://pubmed.ncbi.nlm.nih.gov/25080540/
Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status.
Cao C, Pressman EK, Cooper EM, Guillet R, Westerman M, O'Brien KO. Reproduction. 2014 148(3):295-302. https://pubmed.ncbi.nlm.nih.gov/24947444/
Increased serum hepcidin levels in patients with porphyria cutanea tarda.
Darwich E, To-Figueras J, Molina-López RA, Deulofeu R, Olbina G, Westerman M, Sánchez-Tápias JM, Muñoz-Santos C, Herrero C. J Eur Acad Dermatol Venereol. 2013 27(1):e68-74. https://pubmed.ncbi.nlm.nih.gov/22429447/
Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy.
Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, Busch MP, Olbina G, Westerman M, Nemeth E, Ganz T; NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II). Haematologica. 2013 98(8):1324-30. https://pubmed.ncbi.nlm.nih.gov/23445875/
Low preoperative hepcidin concentration as a risk factor for mortality after cardiac surgery: a pilot study.
Haase-Fielitz A, Plaß M, Kuppe H, Hetzer R, Ostland V, Westphal S, Hoffmann J, Prowle J, Mertens PR, Westerman M, Bellomo R, Haase M. J Thorac Cardiovasc Surg. 2013 145(5):1380-6. https://pubmed.ncbi.nlm.nih.gov/23062413/
Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: results of a phase 1, randomized, open-label trial.
Doyle MK, Rahman MU, Frederick B, Birbara CA, de Vries D, Toedter G, Wu X, Chen D, Ranganath VK, Westerman ME, Furst DE. Rheumatology (Oxford). 2013 52(7):1214-9. https://pubmed.ncbi.nlm.nih.gov/23418046/
Iron homeostasis during cystic fibrosis pulmonary exacerbation.
Gifford AH, Moulton LA, Dorman DB, Olbina G, Westerman M, Parker HW, Stanton BA, O'Toole GA. Clin Transl Sci. 2012 5(4):368-73. https://pubmed.ncbi.nlm.nih.gov/22883617/
Hepcidin concentrations in serum and urine correlate with iron homeostasis in preterm infants.
Müller KF, Lorenz L, Poets CF, Westerman M, Franz AR. J Pediatr. 2012 160(6):949-53. https://pubmed.ncbi.nlm.nih.gov/22284565/
Iron metabolism in patients with anorexia nervosa: elevated serum hepcidin concentrations in the absence of inflammation.
Papillard-Marechal S, Sznajder M, Hurtado-Nedelec M, Alibay Y, Martin-Schmitt C, Dehoux M, Westerman M, Beaumont C, Chevallier B, Puy H, Stheneur C. Am J Clin Nutr. 2012 95(3):548-54. https://pubmed.ncbi.nlm.nih.gov/22301927/
Greater increase in urinary hepcidin predicts protection from acute kidney injury after cardiopulmonary bypass.
Prowle JR, Ostland V, Calzavacca P, Licari E, Ligabo EV, Echeverri JE, Bagshaw SM, Haase-Fielitz A, Haase M, Westerman M, Bellomo R. Nephrol Dial Transplant. 2012 27(2):595-602. https://pubmed.ncbi.nlm.nih.gov/21804084/
Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources.
Young MF, Griffin I, Pressman E, McIntyre AW, Cooper E, McNanley T, Harris ZL, Westerman M, O'Brien KO. J Nutr. 2012 142(1):33-9. https://pubmed.ncbi.nlm.nih.gov/22113871/
Urine hepcidin has additive value in ruling out cardiopulmonary bypass-associated acute kidney injury: an observational cohort study.
Haase-Fielitz A, Mertens PR, Plass M, Kuppe H, Hetzer R, Westerman M, Ostland V, Prowle JR, Bellomo R, Haase M. Crit Care. 2011 15(4):R186. https://pubmed.ncbi.nlm.nih.gov/21816077/
Hepcidin and disordered mineral metabolism in chronic kidney disease.
Carvalho C, Isakova T, Collerone G, Olbina G, Wolf M, Westerman M, Gutiérrez OM. Clin Nephrol. 2011 76(2):90-8. https://pubmed.ncbi.nlm.nih.gov/21762639/
Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project.
Piperno A, Galimberti S, Mariani R, Pelucchi S, Ravasi G, Lombardi C, Bilo G, Revera M, Giuliano A, Faini A, Mainini V, Westerman M, Ganz T, Valsecchi MG, Mancia G, Parati G; HIGHCARE investigators. Blood. 2011 Mar 117(10):2953-9. https://pubmed.ncbi.nlm.nih.gov/21149632/
A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.
Girelli D, Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Westerman M, Ganz T, Nemeth E, Piperno A, Camaschella C. Haematologica. 2011 96(4):500-6. https://pubmed.ncbi.nlm.nih.gov/21173098/
Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation: Does This Protect from Excessive Parenchymal Iron Loading?
Eisfeld AK, Westerman M, Krahl R, Leiblein S, Liebert UG, Hehme M, Teupser D, Niederwieser D, Al-Ali HK. Adv Hematol. 2011 2011:491058. https://pubmed.ncbi.nlm.nih.gov/21687645/
Subcutaneous adipose tissue from obese and lean adults does not release hepcidin in vivo.
Tussing-Humphreys L, Frayn KN, Smith SR, Westerman M, Dennis AL, Nemeth E, Thomson J, Pusatcioglu C. Scientific World Journal. 2011 11:2197-206. https://pubmed.ncbi.nlm.nih.gov/22125467/
Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome.
Ghoti H, Fibach E, Westerman M, Gordana O, Ganz T, Rachmilewitz EA. Br J Haematol. 2011 153(1):118-20. https://pubmed.ncbi.nlm.nih.gov/21332711/
Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors.
Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. Haematologica. 2011 96(8):1099-105. https://pubmed.ncbi.nlm.nih.gov/21508121/
Diagnostic accuracy of serum hepcidin for iron deficiency in critically ill patients with anemia.
Lasocki S, Baron G, Driss F, Westerman M, Puy H, Boutron I, Beaumont C, Montravers P. Intensive Care Med. 2010 36(6):1044-8. https://pubmed.ncbi.nlm.nih.gov/20213069/
Urinary hepcidin: an inverse biomarker of acute kidney injury after cardiopulmonary bypass?
Prowle JR, Westerman M, Bellomo R. Curr Opin Crit Care. 2010 16(6):540-4. https://pubmed.ncbi.nlm.nih.gov/20736824/
Reduction of serum hepcidin by hemodialysis in pediatric and adult patients.
Zaritsky J, Young B, Gales B, Wang HJ, Rastogi A, Westerman M, Nemeth E, Ganz T, Salusky IB. Clin J Am Soc Nephrol. 2010 5(6):1010-4. https://pubmed.ncbi.nlm.nih.gov/20299375/
Iron-deficiency anemia in Castleman disease: implication of the interleukin 6/hepcidin pathway.
Arlet JB, Hermine O, Darnige L, Ostland V, Westerman M, Badoual C, Pouchot J, Capron L. Pediatrics. 2010 126(6):e1608-12. https://pubmed.ncbi.nlm.nih.gov/21041280/
Utilization of iron from an animal-based iron source is greater than that of ferrous sulfate in pregnant and nonpregnant women.
Young MF, Griffin I, Pressman E, McIntyre AW, Cooper E, McNanley T, Harris ZL, Westerman M, O’Brien KO. J Nutr. 2010 140(12):2162-6. https://pubmed.ncbi.nlm.nih.gov/20980658/
Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.
Bachman E, Feng R, Travison T, Li M, Olbina G, Ostland V, Ulloor J, Zhang A, Basaria S, Ganz T, Westerman M, Bhasin S. J Clin Endocrinol Metab. 2010 95(10):4743-7. https://pubmed.ncbi.nlm.nih.gov/20660052/
Maternal serum hepcidin is low at term and independent of cord blood iron status.
Rehu M, Punnonen K, Ostland V, Heinonen S, Westerman M, Pulkki K, Sankilampi U. Eur J Haematol. 2010 85(4):345-52. https://pubmed.ncbi.nlm.nih.gov/20528904/
Hepcidin in trauma: linking injury, inflammation, and anemia.
Sihler KC, Raghavendran K, Westerman M, Ye W, Napolitano LM. J Trauma. 2010 69(4):831-7. https://pubmed.ncbi.nlm.nih.gov/20938270/
Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables, and anemia response.
Katodritou E, Ganz T, Terpos E, Verrou E, Olbina G, Gastari V, Hadjiaggelidou C, Varthaliti M, Georgiadou S, Westerman M, Zervas K. Am J Hematol. 2009 84(8):524-6. https://pubmed.ncbi.nlm.nih.gov/19536845/
Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women.
Young MF, Glahn RP, Ariza-Nieto M, Inglis J, Olbina G, Westerman M, O'Brien KO. Am J Clin Nutr. 2009 89(2):533-8. https://pubmed.ncbi.nlm.nih.gov/19073788/
Hepcidin--a potential novel biomarker for iron status in chronic kidney disease.
Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB. Clin J Am Soc Nephrol. 2009 4(6):1051-6. https://pubmed.ncbi.nlm.nih.gov/19406957/
Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism.
Troadec MB, Lainé F, Daniel V, Rochcongar P, Ropert M, Cabillic F, Perrin M, Morcet J, Loréal O, Olbina G, Westerman M, Nemeth E, Ganz T, Brissot P. Eur J Appl Physiol. 2009 106(3):435-43. https://pubmed.ncbi.nlm.nih.gov/19306018/
Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin.
Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V, Abergel A, Philippe P, Deugnier Y, Coudray C. J Hepatol. 2009 50(6):1219-25. https://pubmed.ncbi.nlm.nih.gov/19398238/
Immunoassay for human serum hepcidin.
Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Blood. 2008 112(10):4292-7. https://pubmed.ncbi.nlm.nih.gov/18689548/
Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency.
Guillem F, Lawson S, Kannengiesser C, Westerman M, Beaumont C, Grandchamp B. Blood. 2008 112(5):2089-91. https://pubmed.ncbi.nlm.nih.gov/18596229/
A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron.
Melis MA, Cau M, Congiu R, Sole G, Barella S, Cao A, Westerman M, Cazzola M, Galanello R. Haematologica. 2008 93(10):1473-9. https://pubmed.ncbi.nlm.nih.gov/18603562/